The research desk

24 references across product documentation, ingredient studies, botanical chemistry, cosmetic safety and delivery technology. Each reference names its research area and links to the source for the complete methods and findings.

01 / Product information

432ONE · the published formula

Monoskin. 432ONE Cream. Official product listing.

Product identity, ingredient declaration and directions.

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02 / 432ONE dermatological testing

Sensitive-skin testing certificate

C.L.A.I.M.S. Pvt. Ltd. Certificate CL/144/1125/STU. 7 January 2026. Batch CP-SRGC-029-015-002.

Adult participants: 50% normal skin and 50% sensitive skin. Nasolabial-area testing; Non-Irritant classification, based on IS 4011:2018.

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03 / Human ingredient research

Centella asiatica · post-laser research

Damkerngsuntorn W, et al. J Altern Complement Med. 2020. DOI: 10.1089/acm.2019.0325. PMID: 32310680.

A randomised, double-blind, split-face study of a standardised Centella extract in a 0.05% ECa 233 gel following Er:YAG laser resurfacing.

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04 / Laboratory ingredient research

Oat beta-glucan · barrier mechanisms

Gao S, et al. Int J Biol Macromol. 2021;185:876–889. DOI: 10.1016/j.ijbiomac.2021.07.002. PMID: 34237364.

Research into oat beta-glucan, epidermal differentiation and barrier-related cell signalling.

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05 / Human ingredient research

Hyaluronic acid · hydration

Pavicic T, et al. J Drugs Dermatol. 2011;10(9):990–1000. PMID: 22052267.

A study of cream formulations containing hyaluronic acid of different molecular weights, examining hydration, elasticity and wrinkle parameters.

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06 / Human & laboratory ingredient research

Niacinamide · skin-tone research

Hakozaki T, et al. Br J Dermatol. 2002;147(1):20–31. DOI: 10.1046/j.1365-2133.2002.04834.x. PMID: 12100180.

Research on niacinamide, melanosome transfer and pigmentation, including specifically formulated topical products.

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07 / Delivery technology

The Cetosomes patent

Barathur RR, Bookout JB. US9084818B2. Granted 21 July 2015. Assignee: Cymbiotics Inc.

Topical dermal delivery compositions using self-assembling nanoparticles with cetylated components.

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08 / Human formulation research

Niacinamide-containing moisturiser

Draelos ZD, Ertel K, Berge C. Cutis. 2005;76(2):135–141. PMID: 16209160.

A controlled study investigating a niacinamide-containing facial moisturiser and skin-barrier parameters in adults with rosacea.

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09 / Dermatology guidance

Introducing a new skincare product

American Academy of Dermatology. How to test skin care products.

Practical guidance for trying a new product on a small area before adding it to your routine.

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10 / Cosmetic ingredient safety assessment

Milk Protein · published safety assessment

Burnett CL, et al. Int J Toxicol. 2022;41(2_suppl):43S–56S. DOI: 10.1177/10915818221098137.

An expert assessment of bovine milk proteins and protein-derived cosmetic ingredients, including their conditioning uses and safety data.

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11 / Human formulation study

Panthenol · barrier recovery after irritation

Proksch E, Nissen HP. J Dermatolog Treat. 2002;13(4):173–178. DOI: 10.1080/09546630212345674.

A controlled study of a dexpanthenol-containing cream following experimentally induced irritation; hydration, redness and barrier recovery were assessed.

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12 / Human formulation study

Panthenol · hydration and water loss

Gehring W, Gloor M. Arzneimittelforschung. 2000;50(7):659–663. DOI: 10.1055/s-0031-1300268.

A randomised, double-blind, vehicle-controlled study of dexpanthenol in two lipophilic vehicles over seven days.

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13 / Related oat research · human & laboratory

Avena Sativa · colloidal oatmeal and the barrier

Ilnytska O, et al. J Drugs Dermatol. 2016;15(6):684–690. PMID: 27272074.

Colloidal oatmeal extracts were studied in laboratory models, alongside a lotion study in 50 women with dry lower-leg skin. Read for the exact oat preparation.

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14 / Related oat research · human & laboratory

Avena Sativa · colloidal oatmeal and skin comfort

Reynertson KA, et al. J Drugs Dermatol. 2015;14(1):43–48. PMID: 25607907.

Laboratory assays and a lotion study in 29 women examined colloidal oatmeal preparations and dry, itchy skin.

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15 / Human constituent study

Liquorice · topical liquiritin

Amer M, Metwalli M. Int J Dermatol. 2000;39(4):299–301. DOI: 10.1046/j.1365-4362.2000.00943.x.

A split-face study in 20 women compared a liquiritin cream with its vehicle. Liquiritin is a liquorice constituent; read the paper for the studied preparation.

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16 / Human ingredient formulation study

Ichthyol Pale · UVB erythema model

Warnecke J, Wendt A. Inflamm Res. 1998;47(2):75–78. DOI: 10.1007/s000110050282.

A controlled study examining pale sulfonated shale oil preparations in an experimental UVB erythema model.

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17 / Human ingredient formulation study

Hamamelis · lotion and UVB erythema

Dermatology. 1998;196(3):316–322. DOI: 10.1159/000017904.

Research comparing hamamelis lotion preparations using a UVB erythema test. Read the source for its vehicles, concentrations and methods.

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18 / Human formulation study

Glycerin · glycerol-based emollient research

Controlled prospective study. PMID: 18025807.

A four-week, randomised, double-blind study in 24 people with atopic dermatitis evaluated a glycerol-based emollient and skin measurements.

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19 / Botanical chemistry · isolated compounds

Arisaema Amurense · constituent chemistry

Jung JH, Lee CO, Kim YC, Kang SS. J Nat Prod. 1996;59(3):319–322. DOI: 10.1021/np960201+.

A phytochemistry paper identifying isolated cerebrosides from Arisaema amurense. This is background reading on the plant’s chemistry.

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20 / Preclinical ingredient research

Allantoin · experimental tissue-repair research

Araújo LU, et al. Acta Cir Bras. 2010;25(5):460–466. DOI: 10.1590/S0102-86502010000500014.

An animal-model study investigating tissue-repair processes with allantoin. Read the complete experimental methods and histological findings.

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21 / Related oat research · human formulation

Avena Sativa · 1% colloidal oat cream

J Drugs Dermatol. 2020;19(5). DOI: 10.36849/JDD.2020.4924. PMID: 32484623.

A randomised study compared a 1% colloidal oat cream with a standard moisturiser in mild-to-moderate eczema, assessing the microbiome and barrier.

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22 / Vitamin E fraction · laboratory & human research

Tocotrienol · UV-induced skin responses

Yap WN. J Cosmet Dermatol. 2018;17(3):555–565. DOI: 10.1111/jocd.12421.

A bench-to-bedside investigation of a tocotrienol-rich fraction and UV-associated skin responses. Read the source for the specific fraction and study design.

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23 / Related hyaluronic acid research · human formulation

Hyaluronic acid · topical serum evaluation

Draelos ZD, et al. Dermatol Ther (Heidelb). 2021;11(4):1385–1394. DOI: 10.1007/s13555-021-00566-0.

A clinical evaluation of a specific topical hyaluronic acid serum in facial photoaging. Explore its formulation and measured outcomes.

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24 / Human ingredient formulation study

Centella Asiatica · moisturising formulations

Ratz-Łyko A, Arct J, Pytkowska K. Indian J Pharm Sci. 2016;78(1):27–33. DOI: 10.4103/0250-474X.180247.

A four-week study of cosmetic emulsions and hydrogels containing Centella extract, assessing hydration and skin responses.

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For a closer professional look

Our professional summary brings together the formulation, certificate and practical product information.

FOR HEALTHCARE PROFESSIONALS