Post-shower. Post-actives. Same one.
One familiar moisturising step for morning and evening. Follow your active routine’s recommended order.
Find its place ↗432ONE / ONE CREAM. MANY ROLES.
COUNT ONONE.
Suitable for sensitive skinSoothing care. Blemish care. Nourishment.
One moisturising relief cream for your real-life routine.
50 g · No added fragrance · Dermatologically tested [2]
01 / THE ONE YOU KEEP CLOSE
One tube.
Many moments.
Bathroom shelf. Makeup bag. Next boarding gate. Your moisturising step goes where you go.
After the appointment.
Moisturising care after laser, peels or microneedling, at the time your clinician recommends.
Find its place ↗
Good skin prep starts here.
A moisturising step before the rest of your getting-ready routine.
Find its place ↗
Out of office. Still your one.
One familiar moisturising step, wherever the day takes you.
Find its place ↗And for dermatologist-guided aftercare? There’s a place for that, too.
Explore aftercare ↗FIND YOUR MOMENT
What’s your skin
dealing with?
Seven familiar situations. Find where your one fits.
01Retinoid routines
Tretinoin · adapalene · retinol
Dry. Tight. Flaking at the corners.
Make 432ONE your moisturising step around an active routine. Follow your dermatologist’s or product label’s instructions for order, frequency and buffering.
See where it fits ↗02Post-laser care
Fractional · Q-switch · resurfacing
After the appointment. Before the everyday.
Your practitioner sets the aftercare timeline. Once moisturising topicals can resume, include 432ONE according to their directions.
See where it fits ↗03Post-peel care
Glycolic · salicylic · TCA
A little extra care after your peel.
For skin that feels dry or tight after a peel, discuss 432ONE as your moisturising step. Start when your practitioner advises.
See where it fits ↗04Microneedling aftercare
Microneedling · RF microneedling
Make room for recovery care.
Your treating clinician decides when and how topical skincare resumes. Keep 432ONE within that individual aftercare plan.
See where it fits ↗05Sensitive skin
Sensitive · reactive-feeling skin
Comfort belongs in your everyday.
Suitable for sensitive skin, dermatologically tested and with no added fragrance. Explore the full ingredients and introduce new skincare gradually.
See where it fits ↗06Acne-prone routines
Blemish-prone · active-heavy routines
Your treatment. Your moisturising step.
432ONE’s featured blemish-care group sits within a moisturising formula. Include it alongside your dermatologist-led acne routine to support daily comfort.
See where it fits ↗07Makeup preparation
Everyday makeup · bridal · editorial
Good makeup starts before foundation.
Apply a thin layer to clean skin and let it settle. In the morning, follow with sunscreen before makeup. A moisturising step for your getting-ready routine.
See where it fits ↗02 / THE NAME IS THE FORMULA’S INTRODUCTION
4 soothe. 3 care.
2 nourish. ONE delivers.
4 / SOOTHING AGENTS
Comfort comes first.
Four featured ingredients at the heart of the soothing story.
Centella Asiatica Extract
CICAA botanical ingredient featured in the soothing group. Explore research into standardised Centella preparations. [3]
Explore the ingredient researchCentella asiatica · post-laser research · [3] ↗Centella Asiatica · moisturising formulations · [24] ↗
Hamamelis Virginiana
WITCH HAZELWitch hazel appears in the published formula alongside Benzoic Acid. It is one of the four featured soothing agents. [1]
Explore the ingredient researchHamamelis · lotion and UVB erythema · [17] ↗
Beta Glucan
OAT BETA-GLUCANA polysaccharide featured in the comfort story. Explore laboratory research on oat beta-glucan and barrier-related mechanisms. [4]
Explore the ingredient researchOat beta-glucan · barrier mechanisms · [4] ↗Avena Sativa · colloidal oatmeal and the barrier · [13] ↗
Sodium Hyaluronate
HYALURONIC ACID SALTA humectant ingredient used to attract and hold water in moisturising formulas. [5]
Explore the ingredient researchHyaluronic acid · hydration · [5] ↗Hyaluronic acid · topical serum evaluation · [23] ↗
3 / BLEMISH CARE
Consider every detail.
The three featured components of the blemish-care group.
Arisaema Amurense Extract
MELAZERO BLENDThe published ingredient entry also includes Decyl Glucoside and 1,2-Hexanediol. Melazero is featured in the brand’s blemish-care framework. [1]
Explore the ingredient researchArisaema Amurense · constituent chemistry · [19] ↗
Ictasol
ICHTHYOL PALEIctasol is the name used in the published ingredient list for the Ichthyol Pale component of the framework. [1]
Explore the ingredient researchIchthyol Pale · UVB erythema model · [16] ↗
Glycyrrhiza Glabra Root Extract
LIQUORICE ROOT EXTRACTThe published formula names Glycyrrhiza Glabra (Licorice) Root Extract within its botanical ingredients. [1]
Explore the ingredient researchLiquorice · topical liquiritin · [15] ↗
2 / NOURISHING AGENTS
A little nourishment.
Oat extract and milk protein complete the featured ingredient groups.
Avena Sativa Kernel Extract
OAT KERNEL EXTRACTThe oat-extract component appears in the published formula; Avenoplex is featured in the nourishing group. [1]
Milk Protein
CONDITIONING INGREDIENTOne of the two featured nourishing agents. Read all the ingredients in the complete formula. [1]
Explore the ingredient researchMilk Protein · published safety assessment · [10] ↗
ONE / CETOSOMES® TECHNOLOGY
Bring it together.
The Cetosomes delivery platform, identified by Monoskin and described in the Cymbiotics patent, completes the 432ONE framework. [7]
Explore the delivery design ↗4 + 3 + 2 = nine featured agents. ONE delivery technology brings the framework together.
Read the full ingredients ↗03 / THE WHOLE FORMULA
There’s more
in your one.
Hydration, softness and conditioning. Read the ingredients together.
Draw moisture in.
Humectants attract water and contribute to the cream’s moisturising role. [5]
Glycerin · Sodium Hyaluronate · Panthenol · Xylitylglucoside / Anhydroxylitol / Xylitol
Think beyond one active.
Niacinamide, botanical ingredients and conditioning components share one formulation. [8]
Niacinamide · Allantoin · Centella Asiatica Extract · Beta Glucan
The feel matters.
Emollient components contribute softness and spread. Tocopherol and tocotrienol add vitamin E chemistry.
Dimethicone · Cetyl Ester Wax · Cetostearyl Alcohol · Tocopherol / Tocotrienol
04 / A MOMENT FOR YOUR SKIN
Less ritual.
More routine.
Clean skin. A little cream. A gentle massage. Make moisturising a moment you look forward to.
Find your daily routine ↗
05 / FITS INTO YOUR LIFE
Your routine.
Meet your one.
Keep your everyday simple.
- Cleanse gently and pat skin dry.
- Apply 432ONE to your face and neck; massage gently until absorbed.
- In the morning, follow with suitable broad-spectrum sunscreen.
Use morning and evening, or as directed on your pack or by your clinician.
Read the full guide ↗Your actives. Your comfort step.
- Cleanse gently and let your skin dry.
- Use your active at the frequency and in the order your dermatologist or product label recommends.
- Include 432ONE as your moisturising step, following that same plan.
For tretinoin, adapalene and other prescribed treatments, your clinician sets the application order and any buffering instructions.
Read the full guide ↗Make space for skin prep.
- Start with clean skin.
- Apply a thin layer of 432ONE and allow it to settle.
- In the morning, apply sunscreen, let it settle, then continue with makeup.
Start with a small amount and check how your chosen products layer together.
Read the full guide ↗Aftercare starts with your clinician.
- Ask your treating clinician when to begin moisturising after your procedure.
- Apply 432ONE when advised, using their recommended amount and frequency.
- Follow your aftercare plan for cleansing, sun protection and any prescribed products.
This applies to laser, peels and microneedling; aftercare timing is individual to the procedure.
Read the full guide ↗
06 / COMFORT, CONSIDERED
Suitable for
sensitive skin.
Dermatologically tested with adults with normal and sensitive skin. [2]
TESTED BATCH CLASSIFICATIONNon-Irritant.
Read the testing certificate ↗07 / THE SCIENCE INSIDE ONE
Good ingredients.
Considered delivery.
Cetosomes® is the delivery platform used in 432ONE. Its patent describes self-assembling particles formed with cetylated components, with a design that accommodates water-soluble and oil-soluble agents. [7]
Explore the science ↗THE 432ONE POCKET GUIDE
A good routine.
On one page.
AM / PM / YOUR NOTESMONOSKIN ↗
08 / YOUR ROUTINE, TO KEEP
Take the good
stuff with you.
Your free guide to everyday moisturising, making room for actives and preparing questions for your dermatologist.
GET THE FREE GUIDEAsk for the guide + offer on WhatsApp ↗
WhatsApp opens a conversation with Monoskin. Send the prepared message when you’re ready. You can also read and print the guide immediately.
YOUR EVERYDAY 50 g
09 / YOUR NEXT DAILY ESSENTIAL
Make it
your one.
432ONE™ All Purpose Relief Cream · 50 g
Suitable for sensitive skin.
₹1,215₹1,350
With RELIEF · 10% off MRP · taxes included
CODE: RELIEF
Quantity₹1,215 with code
SHOP WITH 10% OFFProduct & manufacturer details
50 g · Cosmetic cream · Made in India. Best before 18 months from manufacture; see the received pack for batch details. Manufactured by Cymbiotics Biopharma Pvt. Ltd., Baddi, under licence from Cymbiotics Inc., USA. Marketed by Monocure Pharma. Full addresses and customer care appear below.
What is 432ONE used for?
432ONE is a moisturising relief cream for sensitive skin and daily skin comfort. It brings together the 4–3–2–ONE formulation framework and Cetosomes delivery technology. It can fit into an everyday routine, moisturising care alongside actives and dermatologist-guided aftercare.
What does 4–3–2–ONE mean?
Four featured soothing agents, three blemish-care agents, two nourishing agents and one Cetosomes delivery platform. The full formula also includes supporting ingredients such as niacinamide, panthenol, allantoin and glycerin.
Is 432ONE suitable for sensitive skin?
Yes. 432ONE is labelled suitable for sensitive skin. The supplied dermatological testing certificate includes adults with normal and sensitive skin, and classifies the tested batch as Non-Irritant. Read the testing certificate.
Can I use 432ONE with tretinoin, retinol or adapalene?
432ONE can serve as the moisturising step in an active routine. Follow your dermatologist’s instructions or the active product’s label for order, frequency and buffering. Explore the routine guide.
Can I use it after a peel, laser or microneedling?
432ONE is positioned for dermatologist-guided post-procedure moisturising care. Your treating clinician should set the starting time and application instructions for your specific procedure. Read the aftercare guide.
Can acne-prone skin use 432ONE?
432ONE is positioned for sensitive and blemish-prone skin. It provides a moisturising step alongside an appropriate acne-care routine. Choose products with your dermatologist when you have active acne, and follow your treatment plan.
Can I use 432ONE before makeup?
Use it as a moisturising preparation step: apply a thin layer to clean skin and let it settle before your next products. In the morning, follow with suitable sunscreen and allow that to settle before makeup.
How often should I apply it?
Apply an adequate amount to clean, dry skin over the face and neck and massage gently until absorbed. Use morning and evening, or as directed by your physician. Follow the current pack instructions.
Does it contain added fragrance?
432ONE is declared to have no added fragrance. Its ingredients are available in full for you to explore. Read every ingredient.
Is 432ONE a steroid cream?
432ONE is a non-steroidal cosmetic moisturiser. Read the complete ingredient list and follow your clinician’s plan for any prescribed products.
What are Cetosomes?
Cetosomes are the delivery platform identified by Monoskin for 432ONE. The associated patent describes self-assembling particles made with cetylated components. Explore the patent.
What is the size and price?
432ONE comes in a 50 g tube with an MRP of ₹1,350, inclusive of taxes. Use RELIEF for the advertised 10% offer: ₹1,215 for one tube when the code is accepted at checkout. Shipping and final totals are confirmed by the shop.
How do I use RELIEF?
Copy RELIEF or use a purchase button on this page, which passes the code to Shopify. Check that the discount appears in your order summary before paying. Open the product with the code.
Where can I read the full formula?
The complete published ingredient list is available below and on our dedicated ingredients page, along with a glossary of selected components. Explore the formula.
How is it different from WeCalm?
432ONE is a 50 g cream built around its 4–3–2–ONE featured-agent framework. WeCalm is a 100 ml lotion whose published formula includes ceramides NP, AP and EOP, cholesterol and phytosphingosine. Select the formula that fits your routine and your clinician’s guidance. Explore WeCalm.
How do I introduce a new cream?
Check the ingredients for known sensitivities and try a new skincare product on a small area first. Stop use if irritation develops. After a procedure, follow your clinician’s instructions for when and where to apply products. Read AAD guidance.
Who makes 432ONE?
432ONE is manufactured in India by Cymbiotics Biopharma Pvt. Ltd., Baddi, under licence from Cymbiotics Inc., USA, and marketed by Monocure Pharma. Full manufacturer and seller information appears in the product details.
11 / EVERY INGREDIENT, ALL HERE
The front introduces.
The back explains.
Open the complete published ingredient list
Aqua, Cetyl Ester Wax, Propylene Glycol, Dimethicone, Hamamelis Virginiana (Witch Hazel) (and) Benzoic Acid, Milk Protein, PEG 100 Stearate, Cetostearyl Alcohol, Niacinamide, Glycerin, Isopropyl Myristate, PEG-40 Hydrogenated Castor Oil, Avena Sativa (Oat) Kernel Extract, Carbomer, Arisaema Amurense Extract (and) Decyl Glucoside (and) 1,2-Hexanediol, Glycyrrhiza Glabra (Licorice) Root Extract, Xylitylglucoside (and) Anhydroxylitol (and) Xylitol, Caffeine, Beta Glucan, Cyclodextrin and Centella Asiatica Extract, Ictasol, Panthenol, Allantoin, Caesalpinia Spinosa Fruit Pod Extract / Caesalpinia Spinosa Fruit Extract (and) Helianthus Annuus (Sunflower) Sprout Extract (and) Propylene Glycol (and) Phenoxyethanol (and) Sodium Benzoate, Sodium Gluconate, Sodium Hyaluronate, Triethanolamine, Phenoxyethanol (and) Ethylhexylglycerin, Tocotrienol (and) Tocopherol (and) Medium Chain Triglycerides.
For the beautifully curious.
All references ↗Sensitive-skin testing certificate
C.L.A.I.M.S. Pvt. Ltd. Certificate CL/144/1125/STU. 7 January 2026. Batch CP-SRGC-029-015-002.
Read the certificate ↗Centella asiatica · post-laser research
Damkerngsuntorn W, et al. J Altern Complement Med. 2020. DOI: 10.1089/acm.2019.0325. PMID: 32310680.
Read the source ↗Hyaluronic acid · hydration
Pavicic T, et al. J Drugs Dermatol. 2011;10(9):990–1000. PMID: 22052267.
Read the source ↗The Cetosomes patent
Barathur RR, Bookout JB. US9084818B2. Granted 21 July 2015. Assignee: Cymbiotics Inc.
Read the source ↗Product documentation, ingredient research and technology references. Explore each source for its formulation, methods and findings.
YOUR SKIN. YOUR ROUTINE. YOUR ONE.
COUNT ON ONE.
EVERY DAY.
432ONE™ · 50 g
Take 10% off with RELIEF.